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Active Ingredients: Tramadol and Acetaminophen
Representative Names: Ultracet

What are acetaminophen; tramadol tablets?
ACETAMINOPHEN; TRAMADOL (Ultracet®) is a combination analgesic that is used to relieve moderate, acute pain such as pain following surgical procedures, including dental surgery. Acetaminophen; tramadol may be used for other types of pain as determined by your health care provider. Generic acetaminophen; tramadol tablets are available.

What should my health care professional know before I take acetaminophen; tramadol?
They need to know if you have any of these conditions:
•an alcohol or drug abuse problem
•blood disease, such as anemia
•breathing difficulty or asthma
•drink more than 3 alcohol-containing drinks per day
•drive or operate machinery or perform hazardous activities
•head injury or brain tumor
•kidney disease
•liver disease
•receiving drugs that lower your ability to fight infection
•seizures (convulsions) or seizure disorder (epilepsy)
•stomach or intestinal problems
•an unusual or allergic reaction to acetaminophen, tramadol, codeine, other pain medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant

How should I take this medicine?
Take acetaminophen; tramadol tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If acetaminophen; tramadol upsets your stomach, take it with food or milk. Do not take more than 2 tablets at a time or more than 8 tablets per day. Higher doses may cause severe side effects, do not take more medication than your prescriber has instructed.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Older patients (> 60 years of age) may have a stronger reaction to this medicine, especially if they have kidney or liver disease.

What if I miss a dose?
If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with acetaminophen; tramadol?
•antihistamines (commonly found in allergy or cold products)
•drugs to regulate heart rhythm such as amiodarone, propafenone, quinidine
•isoniazid, INH
•medicines called MAO inhibitors-phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®), selegiline (Eldepryl®)
•medicines for anxiety, depression, or sleeping problems
•medicines for nausea or vomiting
•medicines for Parkinson's disease such as entacapone, pramipexole, ropinirole or tolcapone
•medicines for mental problems like schizophrenia
•muscle relaxants
•other medicines for pain such as codeine, morphine, nalbuphine, pentazocine, or propoxyphene
•seizure medicines
•stimulants such as amphetamine or dextroamphetamine
•St. John's wort

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking acetaminophen; tramadol?
Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon:
•changes in vision
•difficulty breathing, shortness of breath
•fast or irregular heartbeat
•hallucinations (seeing and hearing things that are not really there)
•not passing urine as often as usual
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•skin rash, itching
•seizures (convulsions)
•yellow tint to your skin or whites of your eyes
More common:
•anxiety, agitation

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
•constipation or diarrhea
•difficulty sleeping
•dizziness, drowsiness
•dry mouth
•false sense of well being, feeling of unreality, mood changes
•sweating or flushing

What should I watch for while taking acetaminophen; tramadol?
Tell your prescriber or health care professional if your pain does not go away.

Do not drive, use machinery, or do anything that needs mental alertness until you know how acetaminophen; tramadol affects you. Be careful taking other medicines which may also make you tired. This effect may be worse when taking these medicines with acetaminophen; tramadol. Alcohol can increase possible drowsiness, dizziness, confusion and affect your breathing. Do not drink alcoholic beverages while taking tramadol.

Your mouth may get dry. Chewing sugarless gum, sucking hard candy and drinking plenty of water will help.

If you are going to have surgery, tell your prescriber or health care professional that you are taking Ultracet®.

Many non-prescription medicines contain acetaminophen as an ingredient. Additional acetaminophen taken with Ultracet® can be dangerous. Always read the labels carefully to avoid taking an accidental overdose of acetaminophen. Report any possible overdose of acetaminophen; tramadol promptly to your health care provider.

Acetaminophen can affect the results from some blood-sugar tests used by diabetic patients. Check with your prescriber or health care professional before you change your diet or the dose of your diabetic medicine.

Where can I keep my medicine?
Keep out of reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


No web site can come near to giving the advice of a health professional. Information on this site is for your guidance only. You should confirm that it is correct for you as an individual, before you use it, by checking it with your own doctor or pharmacist.

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